Optical Coherence Tomography versus Fundus Fluorescein Angiography in Diagnosis of Type 2 CNV in Wet AMD

The most common cause of visual impairment in developed countries, particularly over the ages of 55 is Age related macular degeneration (AMD) [1]. Currently, the WHO has estimated that there will be approximately 8 million people affected by AMD by the year 2020 [2]. Whilst AMD was previously an untreatable disease, the wet form is currently treatable with the advent of anti-vascular endothelial growth factor (anti-VEGF) therapies. Patients who initially present to clinic with suspected AMD are first investigated by optical coherence tomography (OCT). If there is a suspicion of wet AMD, they are also investigated with fundus Fluorescein angiography (FFA) in addition to the OCT scan [3,4]. OCT represents a time-efficient and non-invasive examination technique that constructs two-dimensional images of the posterior pole, whilst FFA is a more-invasive and time-consuming investigation which carries a minimal chance of a severe risk to the patient. Introduction